Zerene Case Study
November 2025
Zerene collected user data to support an internal case study evaluating the impact of biofeedback training on sleep bruxism activity. Across five users, Zerene training was associated with substantial reductions in bruxism-related activity scores.
Snapshot of Results
| User | Demographic | Reported Reduction in Bruxism Activity |
|---|---|---|
| User #1 | ~30-year-old female | 97.5% reduction |
| User #2 | ~45-year-old female | 97.0% reduction |
| User #3 | ~45-year-old male | 95.4% reduction |
| User #4 | ~40-year-old male | 96.4% reduction |
| User #5 | ~35-year-old male | 94.8% reduction |
User #1
Profile
- ~30-year-old female
- Long history of headaches upon waking from sleep
- Previously tried multiple headache medications and different mouthguards without success
- Reported Zerene was more comfortable than other biofeedback devices and felt similar to a standard mouthguard
- Appreciated the ability to track progress through the app
User Review
“I’ve had headaches from teeth grinding for the last 10+ years. I’ve tried multiple headache pain meds, different types of mouth guards (hard and soft). Nothing has worked as good as Zerene. That’s because Zerene stops the source of my headaches – teeth grinding. I wish more people (& doctors) knew about Zerene! If you suffer from headaches from teeth grinding, I 1000% recommend Zerene. It’s worth every penny.”
Results
- Bruxism activity Z-score reduced by 97.5%
- Blue sections of the chart represent nights without biofeedback
- Green sections represent nights with active feedback/training
User #2
Profile
- ~45-year-old female
Works in higher education
User Review
“Definitely worked for me. It took some getting used to wearing it, but now I barely notice it and the biting/clenching is pretty much gone.”
Results
- Bruxism activity Z-score reduced by over 97.0%
- Training data showed a significant reduction after biofeedback began
User #3
Profile
- ~45-year-old male
User Feedback
“Certainly reduced biting, not wanting to go without it or old mouthguard.”
“Grateful for this device existing.”
Results
- Bruxism activity Z-score reduced by 95.4%
- Data suggested behavioral improvements persisted temporarily even after training paused for one week
- Team observation noted that tapering training may help support long-term retention
User #4
Profile
- ~40-year-old male
User Review
“Zerene is easy to use and really made a difference for me. The device is comfortable to wear, and has significantly reduced my jaw pain and discomfort with remarkably durable effect – after a month of use I now find I only need to use it a couple of nights a week.”
“The data helps demonstrate the improvement the device provides, and helped me better understand how bruxism was impacting my quality of sleep.”
“Device fits great.”
“After the 2 week period definitely noticed less jaw pain.”
“Thanks for everything, great experience, setting a low bar for the experience, pleasantly surprised.”
Results
- Bruxism activity Z-score reduced by 96.4%
User #5
Profile
- ~35-year-old male
User Feedback
“Thank you for starting the company and trying something different.”
“Was at wits end until I found this device.”
Results
- Bruxism activity Z-score reduced by 94.8%
